Antonio Valencia, Phil Jones, Eric Bailly, Marouane Fellaini and Marcus Rashford all come into the starting XI.

Daley Blind, Victor Lindelof, Chris Smalling, Paul Pogba and Anthony Martial drop out.

Pogba is set of six weeks of the sidelines after injuring his hamstring in the win against Basel.

Wayne Rooney starts for Everton on his return to Old Trafford.

Ronald Koeman has rung the changes following Thursday’s defeat at Atalanta.

Mason Holgate, Mo Besic, Nikola Vlasic and Dominic Calvert-Lewin drop out with Cuco Martina, Ashley Williams, Idissa Gueye and Tom Davies coming in.

Manchester United: De Gea, Valencia, Jones, Bailly, Young, Matic, Fellaini, Mkhitaryan, Mata, Rashford, Lukaku

Subs: Romero, Darmian, Smalling, Carrick, Herrera, Lingard, Martial

Everton: Pickford, Martina, Keane, Williams, Jagielka, Baines, Schneiderlin, Gueye, Davies, Sigurdsson, Rooney

Subs: Stekelenburg, Ramirez, Mirallas, Klaasen, Besic, Calvert-Lewin, Holgate