Arsenal have won six successive home matches against West Brom in the Premier League but the Baggies beat the Gunners 3-1 at The Hawthorns in March.
Express Sport looks at five key talking points before the match.
Lacazette loves the Emirates
Arsenal’s record signing has made an adequate start to Premier League life with two goals in five appearances.
Manager Arsene Wenger has acknowledged the French striker’s need for time to adapt but Arsenal need him to start scoring regularly.
And fortunately for them, Lacazette loves scoring at the Emirates and he could become the first Arsenal player to score in his opening three league appearances at home since 1988.
Gareth Barry record breaker
Tonight Gareth Barry will become the all-time leading Premier League appearance maker, surpassing the record set by Ryan Giggs at Manchester United.
He’s already played the most minutes (52,871) than any other player and racked up the most yellow cards (119).
The record is a testament to his longevity.
Ozil, Lacazette, Alexis triumvirate
Despite the blow of losing Danny Welbeck to injury, his absence could see the first sighting of Lacazette, Mesut Ozil and Alexis Sanchez together in the starting XI.
For various reasons, the attacking trio have not been able to line-up alongside each other in Arsenal’s first seven games of the season.
If Arsenal are going to achieve their ambitions this season, they will need Lacazette, Ozil and Sanchez to deliver regularly.
Kieran Gibbs returns
Kieran Gibbs returns to the Emirates this evening as a West Brom player for the first time since leaving in the summer.
The left-back ended a 13-year association with the Gunners in a bid to play first-team football and will want to show his old club what they are missing.
Arsenal playing catch up
Already nine points behind leaders Manchester City and Manchester United, Arsenal can ill-afford to slip up against West Brom.
A tough start and defeats against Stoke and Liverpool have left them needing to start playing catch-up just six games into the season.
A win tonight would move them up to seventh, one point behind top four rivals Tottenham and Liverpool.